Sub-chronic effects of Baccharis dracunculifolia treatment on biochemical, oxidative, and histopathological parameters in diabetic rats

Background: Oxidative stress and the mild inflammatory process present in diabetes play a critical role pathogenesis of disease its comorbidities. This understanding has opened new avenues targets for developing improved treatments since risk factors associated with may be reduced through non-pharmacological interventions. In this sense, plant extracts could efficient preventing or assisting these pathological conditions treatment. Methods: Diabetes mellitus was induced 24 rats, which were allocated 4 groups: Control (CT), Control+Baccharis (CT-B), Diabetes (DB), Diabetes+Baccharis (DB-B). For 28 days, animals CT-B DB-B groups treated, via gavage, B. dracunculifolia extract at 50 mg.kg-1. Results: The DB group presented higher values than on parameters such as creatinine (26.42%), urea (31.42%), triglycerides (60.80%). Creatinine (0.39±0.01 e 75.0±8.4, receptively) equivalent to CT (0.32±0.01 71.7±5.4) (0.39±0.01, 58.8±4.5). The treatment levels fasting glucose response tolerance (32%), insulin (52,17%) lipid peroxidation (liver 33.33%, kidney 38.77%) when compared group. Conclusions: phenolic compounds anti-inflammatory activity Baccharis responsible hypoglycemic effect observed study.